Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.64 |
| ▸ | BACE1 | P56817 | 6/20 | 0.61 |
| ▸ | HRH2 | P25021 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 6/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31745353 | 0.85 | JAK1 (0.59) | AXLHRH3BACE1HRH2LTA4H | |
| SCHEMBL4880015 | 0.85 | AIMP2 (0.57) | AXLHRH3BACE1LTA4HPTGS2 | |
| SCHEMBL2498482 | 0.85 | BACE1 (0.63) | AXLBACE1LTA4HPTGS2JAK2 | |
| SCHEMBL4074376 | 0.84 | HRH3 (0.62) | AXLHRH3BACE1JAK2JAK3 | |
| SCHEMBL12109533 | 0.84 | HRH3 (0.77) | AXLHRH3BACE1HRH2LTA4H | |
| SCHEMBL11877770 | 0.84 | HRH3 (0.83) | HRH3HRH2LTA4H | |
| SCHEMBL12278133 | 0.82 | HRH3 (0.69) | AXLHRH3BACE1JAK2JAK3 | |
| SCHEMBL11882995 | 0.82 | HRH3 (0.86) | HRH3HRH2LTA4H | |
| SCHEMBL11877113 | 0.82 | HRH3 (0.86) | HRH3HRH2LTA4H | |
| SCHEMBL264885 | 0.81 | HRH3 (0.70) | AXLHRH3BACE1HRH2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| EP-1802586-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2007-07-04 | — | — | EP | claimed |
| WO-2006044823-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2006-04-27 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |