Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069131 | 0.90 | IGF1R (0.45) | NTRK1IGF1RMAPK1CCNT1CDK9 | |
| SCHEMBL4072748 | 0.89 | NTRK1 (0.47) | NTRK1MAPK1 | |
| SCHEMBL4151801 | 0.85 | NTRK1 (0.59) | NTRK1IGF1R | |
| SCHEMBL4066820 | 0.83 | NTRK1 (0.47) | NTRK1 | |
| SCHEMBL4077780 | 0.80 | NTRK1 (0.56) | NTRK1IGF1R | |
| SCHEMBL4073723 | 0.77 | NTRK1 (0.53) | NTRK1 | |
| SCHEMBL3343540 | 0.77 | NTRK1 (0.54) | NTRK1CCNT1CDK9 | |
| SCHEMBL4148218 | 0.76 | IGF1R (0.58) | NTRK1IGF1R | |
| SCHEMBL4068820 | 0.76 | NTRK1 (0.54) | NTRK1 | |
| SCHEMBL4069692 | 0.76 | NTRK1 (0.51) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |