Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.47 |
| ▸ | GRK6 | P43250 | 5/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156718 | 0.86 | NTRK1 (0.64) | NTRK1 | |
| SCHEMBL4069131 | 0.83 | IGF1R (0.45) | NTRK1 | |
| SCHEMBL4074688 | 0.83 | NTRK1 (0.46) | NTRK1 | |
| SCHEMBL4072356 | 0.81 | NTRK1 (0.55) | NTRK1GRK6AURKA | |
| SCHEMBL4070911 | 0.78 | IGF1R (0.41) | AURKA | |
| SCHEMBL4072748 | 0.77 | NTRK1 (0.47) | NTRK1 | |
| SCHEMBL4073738 | 0.73 | NTRK1 (0.56) | NTRK1GRK6AURKA | |
| SCHEMBL3337098 | 0.73 | NTRK1 (0.74) | NTRK1GRK6 | |
| SCHEMBL30009939 | 0.73 | NTRK1 (0.74) | NTRK1GRK6 | |
| SCHEMBL4065664 | 0.73 | NTRK1 (0.74) | NTRK1GRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |