Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948765 | 0.70 | SIGMAR1 (0.44) | SIGMAR1POLBKMT2AMEN1MAPK1 | |
| SCHEMBL948263 | 0.70 | POLB (0.41) | SIGMAR1POLBKMT2AMEN1CHRM2 | |
| SCHEMBL20917618 | 0.69 | SIGMAR1 (0.44) | SIGMAR1POLBKMT2APARP1MAPK1 | |
| SCHEMBL19899775 | 0.67 | GAA (0.41) | POLBKMT2AMEN1MAPK1CYP1A2 | |
| SCHEMBL20535826 | 0.67 | MAPK1 (0.33) | MAPK1KCNH2 | |
| SCHEMBL28104856 | 0.67 | SIGMAR1 (0.39) | SIGMAR1POLBKMT2AMEN1PARP1 | |
| SCHEMBL16095641 | 0.67 | SIGMAR1 (0.39) | SIGMAR1POLBKMT2AMEN1PARP1 | |
| SCHEMBL20641853 | 0.66 | CYP3A4 (0.45) | POLBKMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1906096 | 0.66 | SIGMAR1 (0.41) | SIGMAR1POLBKMT2AMEN1MAPK1 | |
| SCHEMBL35212079 | 0.66 | SIGMAR1 (0.47) | SIGMAR1POLBKMT2AKCNH2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084155-A1 | THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma S.A. (BE) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008047109-A1 | THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2008-04-24 | — | — | WO | disclosed |