Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.87 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155679 | 0.93 | NTRK1 (1.00) | NTRK1JAK2JAK3 | |
| SCHEMBL4148181 | 0.92 | NTRK1 (0.86) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4165581 | 0.91 | NTRK1 (0.76) | NTRK1 | |
| SCHEMBL4156995 | 0.89 | NTRK1 (0.81) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4144577 | 0.87 | NTRK1 (1.00) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4074781 | 0.86 | NTRK1 (0.65) | NTRK1 | |
| SCHEMBL4147292 | 0.85 | NTRK1 (0.85) | NTRK1 | |
| SCHEMBL4152468 | 0.85 | NTRK1 (0.85) | NTRK1 | |
| SCHEMBL4152595 | 0.85 | NTRK1 (0.85) | NTRK1 | |
| SCHEMBL4156670 | 0.84 | NTRK1 (1.00) | NTRK1JAK2JAK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090005396-A1 | Use of Pyrazolyl-Pyrimidine Derivatives in the Treatment of Pain | ASTRAZENECA AB (SE) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005396-A1 | Use of Pyrazolyl-Pyrimidine Derivatives in the Treatment of Pain | P2RX3, DPYD, TYMP | NTRK1 3656/4885JAK2 1971/4885JAK3 1598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.