⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468906 | 0.85 | REN (0.31) | — | |
| SCHEMBL4532580 | 0.85 | REN (0.33) | — | |
| SCHEMBL4532575 | 0.85 | REN (0.33) | — | |
| SCHEMBL3464847 | 0.83 | REN (0.31) | — | |
| SCHEMBL3464977 | 0.82 | REN (0.33) | — | |
| SCHEMBL4530615 | 0.82 | REN (0.35) | — | |
| SCHEMBL4530619 | 0.82 | REN (0.35) | — | |
| SCHEMBL4531133 | 0.81 | REN (0.47) | — | |
| SCHEMBL9948074 | 0.81 | REN (0.47) | — | |
| SCHEMBL4526046 | 0.78 | REN (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948654-B1 | 5-AMINO-4-HYDROXY-7- (IMIDAZO [1,2-A] PYRIDIN-6- YLMETHYL)-8-METHYL-NONAMIDE DERIVATIVES AND RELATED COMPOUNDS AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2009-06-24 | — | — | EP | disclosed |