⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070373 | 0.81 | — | — | |
| SCHEMBL16519884 | 0.79 | — | — | |
| SCHEMBL2079864 | 0.79 | — | — | |
| SCHEMBL14059079 | 0.78 | DUT (0.30) | — | |
| SCHEMBL5903299 | 0.78 | — | — | |
| SCHEMBL15817363 | 0.77 | — | — | |
| SCHEMBL13612003 | 0.77 | — | — | |
| SCHEMBL1228877 | 0.76 | — | — | |
| SCHEMBL14059474 | 0.75 | DUT (0.35) | — | |
| SCHEMBL23532363 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166177-B | Boron-containing PDE4 inhibitors | 辉瑞公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-117384079-B | Chiral N-alkyl indole compound and preparation method and application thereof | 云南大学 | 2024-05-24 | — | — | CN | disclosed |
| CN-117384079-A | Chiral N-alkyl indole compound and preparation method and application thereof | 云南大学 | 2024-01-12 | — | — | CN | disclosed |
| EP-3861001-B1 | BORON CONTAINING PDE4 INHIBITORS | PFIZER (US) | 2023-12-13 | — | — | EP | disclosed |
| US-20230148402-A1 | Boron Containing PDE4 Inhibitors | PFIZER INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230148402-A1 | Boron Containing PDE4 Inhibitors | PFIZER INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230148402-A1 | Boron Containing PDE4 Inhibitors | PFIZER INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-11559538-B2 | Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors | PFIZER INC. (US) | 2023-01-24 | — | — | US | disclosed |
| EP-3861001-A1 | BORON CONTAINING PDE4 INHIBITORS | Pfizer Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| CN-113166177-A | Boron-containing PDE4 inhibitors | 辉瑞公司 | 2021-07-23 | — | — | CN | disclosed |
| US-20130211074-A1 | INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM | DEMERX, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| WO-2013112163-A1 | INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM | DEMERX, INC. (US) | 2013-08-01 | — | — | WO | disclosed |
| WO-2013112757-A1 | INDOLE AND BENZOFURAN FUSED ISOQUINUCLIDENE DERIVATIVES AND PROCESSES FOR PREPARING THEM | DEMERX, INC. (US) | 2013-08-01 | — | — | WO | disclosed |
| US-20090291998-A1 | EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF | EISAI R&D MANAGEMENT CO., LTD. | 2009-11-26 | — | — | US | disclosed |
| US-20090291998-A1 | EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF | EISAI R&D MANAGEMENT CO., LTD. | 2009-11-26 | — | — | US | disclosed |
| US-7524883-B2 | Eponemycin and epoxomicin analogs and uses thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-04-28 | — | — | US | disclosed |
| US-7524883-B2 | Eponemycin and epoxomicin analogs and uses thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-04-28 | — | — | US | disclosed |
| US-20050101781-A1 | Eponemycin and epoxomicin analogs and uses thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-05-12 | — | — | US | disclosed |
| EP-1463719-A2 | EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF | Eisai Co., Ltd (JP) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059898-A2 | EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF | EISAI CO. LTD. (JP) | 2003-07-24 | — | — | WO | disclosed |