Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499614 | 0.82 | CYP2C19 (0.57) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL12828550 | 0.78 | CYP2C19 (0.48) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL691762 | 0.78 | CYP2C19 (0.57) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL17763415 | 0.77 | CES2 (0.41) | CYP2C19KDM4EHTR2AL3MBTL1CES2 | |
| Ammonia Solution, Strong SCHEMBL11201030 | 0.76 | CYP2C19 (0.55) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL7674344 | 0.76 | CYP2C19 (0.55) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL9003499 | 0.76 | CYP2C19 (0.55) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL3996056 | 0.76 | CYP2C19 (0.55) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL4892666 | 0.75 | CES2 (0.42) | ALOX15HTR2ACES2CES1TRPA1 | |
| SCHEMBL9293127 | 0.75 | CYP2C19 (0.46) | CYP2C19SMN1; SMN2ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102974268-B | alkyl benzyl polyoxyethylene ether betaine surfactant and preparation method and application thereof | CHINESE ACAD TECH INST PHYSICS | 2014-06-25 | — | — | CN | claimed |
| CN-102974268-A | Alkyl benzyl polyoxyethylene ether betaine surfactant and preparation method and application thereof | CHINESE ACAD TECH INST PHYSICS | 2013-03-20 | — | — | CN | claimed |
| CN-102344345-A | Preparation method of arylene ether compound | UNIV NANJING NORMAL | 2012-02-08 | — | — | CN | claimed |
| EP-1169364-B1 | NOVEL ABA TRIBLOCK AND DIBLOCK COPOLYMERS AND METHODS OF PREPARING THE SAME | CALIFORNIA INST OF TECHN (US) | 2009-07-29 | — | — | EP | claimed |
| EP-1169364-A4 | NOVEL ABA TRIBLOCK AND DIBLOCK COPOLYMERS AND METHODS OF PREPARING THE SAME | CALIFORNIA INST OF TECHN (US) | 2003-07-23 | — | — | EP | claimed |
| US-20030013825-A1 | Novel ABA triblock and diblock copolymers and methods of preparing the same | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-01-16 | — | — | US | claimed |
| US-6410666-B1 | CONTACTING A CYCLOALKENE WITH CHAIN TRANSFER AGENT IN PRESENCE OF METATHESIS CATALYST FORMING TELECHELIC POLYMER; REACTING WITH ALKENE | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-06-25 | — | — | US | claimed |
| EP-1169364-A1 | NOVEL ABA TRIBLOCK AND DIBLOCK COPOLYMERS AND METHODS OF PREPARING THE SAME | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2002-01-09 | — | — | EP | claimed |
| WO-2000055218-A1 | NOVEL ABA TRIBLOCK AND DIBLOCK COPOLYMERS AND METHODS OF PREPARING THE SAME | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2000-09-21 | — | — | WO | claimed |
| US-4423198-A | WITH POLYMERIZABLE TERTIARY AMINE AND CROSSLINKER | COPOLYMER RUBBER & CHEMICAL CORPORATION (US) | 1983-12-27 | — | — | US | claimed |
| CN-114573717-A | Preparation method of high-temperature water-retention modified cellulose ether | 南京钧正新材料有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-114573717-A | Preparation method of high-temperature water-retention modified cellulose ether | 南京钧正新材料有限公司 | 2022-06-03 | — | — | CN | disclosed |
| US-10273238-B2 | Indazolones as modulators of TNF signaling | ABBVIE INC. (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180215764-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. | 2018-08-02 | — | — | US | disclosed |
| US-9879016-B2 | Indazolones as modulators of TNF signaling | ABBVIE INC. (US) | 2018-01-30 | — | — | US | disclosed |
| CN-1014790-B | PROCESS FOR PREPARING NOVEL BENZOXAZOL-AND BENZOTHIAZOLAMINE DERIVATIVES AND THEIR USE | JANSSEN PHARMACEUTICA NV (BE) | 1991-11-20 | — | — | CN | disclosed |
| US-5010198-A | Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-23 | — | — | US | disclosed |
| US-4861785-A | Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-29 | — | — | US | disclosed |
| CN-85108556-A | The preparation method of novel benzoxazol base and benzothiazolyl amino derivative and application thereof | — | 1986-07-30 | — | — | CN | disclosed |
| EP-0184257-A1 | Benzoxazol- and benzothiazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215764-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | TNF, TNFRSF9, TNFRSF1A | CYP2C19 293/4885SMN1; SMN2 3536/4885ALDH1A1 930/4885 |
| US-10273238-B2 | Indazolones as modulators of TNF signaling | TNF, TNFRSF9, TNFRSF1A | CYP2C19 293/4885SMN1; SMN2 3536/4885ALDH1A1 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.