Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13765323 | 1.00 | CDC7 (0.42) | CDC7HTR3A | |
| SCHEMBL4084022 | 0.89 | HTR3A (0.47) | HTR3A | |
| SCHEMBL4082461 | 0.87 | KCNH2 (0.45) | HTR3A | |
| SCHEMBL13765320 | 0.77 | HTR3A (0.44) | HTR3A | |
| SCHEMBL4074629 | 0.77 | HTR3A (0.44) | HTR3A | |
| SCHEMBL4076463 | 0.77 | HTR3A (0.47) | HTR3A | |
| SCHEMBL4083086 | 0.77 | HTR3A (0.47) | HTR3A | |
| SCHEMBL4077773 | 0.76 | HTR3A (0.54) | HTR3A | |
| SCHEMBL4074754 | 0.73 | HTR3A (0.53) | HTR3A | |
| SCHEMBL4084284 | 0.67 | HTR3A (0.47) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566727-B2 | 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydro-isoindole-1-one/5,6-dihydro-furo[2,3-c] pyrrol-4-one derivative ligands for alpha 7 nicotinic acetylcholine receptor | ASTRAZENECA AB | 2009-07-28 | — | — | US | claimed |
| US-20070213342-A1 | Novel 2-(1-Aza-Bicyclo[2.2.2.]Oct-3-Yl)-2,3-Dihydro-Isoindole-1-One/5,6-Dihydro-Furo[2,3-C] Pyrrol-4-One Derivative Ligands For Alpha 7 Nicotinic Acetylcholine Receptor | ASTRAZENECA AB (SE) | 2007-09-13 | — | — | US | claimed |
| US-7566727-B2 | 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydro-isoindole-1-one/5,6-dihydro-furo[2,3-c] pyrrol-4-one derivative ligands for alpha 7 nicotinic acetylcholine receptor | ASTRAZENECA AB | 2009-07-28 | — | — | US | disclosed |
| US-20070213342-A1 | Novel 2-(1-Aza-Bicyclo[2.2.2.]Oct-3-Yl)-2,3-Dihydro-Isoindole-1-One/5,6-Dihydro-Furo[2,3-C] Pyrrol-4-One Derivative Ligands For Alpha 7 Nicotinic Acetylcholine Receptor | ASTRAZENECA AB (SE) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213342-A1 | Novel 2-(1-Aza-Bicyclo[2.2.2.]Oct-3-Yl)-2,3-Dihydro-Isoindole-1-One/5,6-Dihydro-Furo[2,3-C] Pyrrol-4-One Derivative Ligands For Alpha 7 Nicotinic Acetylcholine Receptor | CHRNA1, CHRNA7, CHRNE | CDC7 1175/4885HTR3A 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.