Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4076526 | 1.00 | — | — | |
| Bicarbonate SCHEMBL27897666 | 0.94 | — | — | |
| Bicarbonate SCHEMBL27900421 | 0.94 | — | — | |
| Bicarbonate SCHEMBL10746789 | 0.93 | CA1 (0.83) | — | |
| Bicarbonate SCHEMBL5458673 | 0.93 | CA1 (0.83) | — | |
| Bicarbonate SCHEMBL23213376 | 0.93 | CA1 (0.83) | — | |
| Bicarbonate SCHEMBL5458669 | 0.93 | — | — | |
| Bicarbonate SCHEMBL21405704 | 0.93 | — | — | |
| Bicarbonate SCHEMBL8531740 | 0.93 | CA1 (0.83) | — | |
| Bicarbonate SCHEMBL2718215 | 0.93 | CA1 (0.83) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1938244-B | Fluoridation method | GE HEALTHCARE LTD | 2013-03-13 | — | — | CN | disclosed |
| CN-102421454-A | Pet radiotracers for imaging fatty acid metablolism and storage | UNIV WASHINGTON | 2012-04-18 | — | — | CN | disclosed |
| CN-101123995-B | Stilbene derivatives and their use for binding and imaging amyloid plaques | UNIV PENNSYLVANIA | 2011-11-16 | — | — | CN | disclosed |
| CN-101484190-B | Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents | UNIV PENNSYLVANIA | 2011-07-20 | — | — | CN | disclosed |
| CN-101484190-A | Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents | UNIV PENNSYLVANIA (US) | 2009-07-15 | — | — | CN | disclosed |
| EP-1841465-A4 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1838298-A4 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-2012833-A2 | RADIOLABELED DIHYDROTETRABENAZINE DERIVATIVES AND THEIR USE AS IMAGING AGENTS | The Trustees Of The University Of Pennsylvania (US) | 2009-01-14 | — | — | EP | disclosed |
| CN-101123995-A | Stilbene derivatives and their use for binding and imaging amyloid plaques | UNIV PENNSYLVANIA (US) | 2008-02-13 | — | — | CN | disclosed |
| WO-2007130365-A2 | RADIOLABELED DIHYDROTETRABENAZINE DERIVATIVES AND THEIR USE AS IMAGING AGENTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-11-15 | — | — | WO | disclosed |
| EP-1841465-A2 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | The Trustees of The University of Pennsylvania (US) | 2007-10-10 | — | — | EP | disclosed |
| EP-1838298-A2 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | The Trustees of The University of Pennsylvania (US) | 2007-10-03 | — | — | EP | disclosed |
| CN-1938244-A | Fluoridation method | GE HEALTHCARE LTD (GB) | 2007-03-28 | — | — | CN | disclosed |
| WO-2006078384-A2 | STILBENE DERIVATIVES AND THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-07-27 | — | — | WO | disclosed |
| WO-2006066104-A2 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-06-22 | — | — | WO | disclosed |