Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.41 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083632 | 0.78 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL75919 | 0.68 | HSD11B1 (0.50) | HSD11B1IDH1EPHX2 | |
| SCHEMBL704559 | 0.67 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL703444 | 0.67 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL4079302 | 0.67 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL4079034 | 0.67 | HSD11B1 (0.37) | HSD11B1EPHX2 | |
| SCHEMBL4078912 | 0.65 | HSD11B1 (0.42) | HSD11B1MAPK8 | |
| SCHEMBL1116573 | 0.65 | HSD11B1 (0.43) | HSD11B1IDH1EPHX2 | |
| SCHEMBL1116553 | 0.65 | IDH1 (0.37) | HSD11B1IDH1EPHX2 | |
| SCHEMBL2169056 | 0.65 | HSD11B1 (0.46) | HSD11B1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |