Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | LAP3 | P28838 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344226 | 1.00 | PPARG (0.50) | PPARGPPARAFFAR1FFAR4LTA4H | |
| SCHEMBL13537531 | 0.91 | PPARG (0.48) | PPARGPPARAFFAR1FFAR4LTA4H | |
| SCHEMBL23532659 | 0.88 | GPR132 (0.48) | FFAR1ADAM17MAOB | |
| SCHEMBL3172048 | 0.88 | GPR132 (0.48) | FFAR1ADAM17MAOB | |
| SCHEMBL23532660 | 0.88 | GPR132 (0.48) | FFAR1ADAM17MAOB | |
| SCHEMBL2438588 | 0.87 | NPC1 (0.44) | — | |
| SCHEMBL495878 | 0.87 | NPC1 (0.44) | — | |
| SCHEMBL23092514 | 0.87 | NPC1 (0.44) | — | |
| SCHEMBL21979446 | 0.87 | NPC1 (0.44) | — | |
| SCHEMBL3508763 | 0.87 | NPC1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638960-A4 | PREPARATION OF CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| EP-1638960-A2 | PREPARATION OF CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000249-A2 | PREPARATION OF CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |