Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 4/20 | 0.48 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 10/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 7/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278017 | 0.84 | CALCRL (0.55) | CALCRLRAMP1CTSSCNR1GPR55 | |
| SCHEMBL13313602 | 0.81 | CALCRL (0.47) | CALCRLRAMP1CTSSNSD3DRD2 | |
| SCHEMBL13907972 | 0.81 | CALCRL (0.47) | CALCRLRAMP1CTSSCNR1GPR55 | |
| SCHEMBL12400695 | 0.81 | CALCRL (0.47) | CALCRLRAMP1CTSSCNR1GPR55 | |
| SCHEMBL13801339 | 0.80 | CALCRL (0.46) | CALCRLRAMP1CTSSCNR1GPR55 | |
| Bicarbonate SCHEMBL5261153 | 0.80 | NSD3 (0.50) | CALCRLRAMP1CTSSNSD3 | |
| SCHEMBL12219072 | 0.79 | HPGD (0.46) | CALCRLRAMP1CTSSCNR1CNR2 | |
| SCHEMBL12622796 | 0.79 | CALCRL (0.53) | CALCRLRAMP1CTSSCNR1GPR55 | |
| SCHEMBL2257145 | 0.78 | NSD3 (0.53) | CALCRLRAMP1CTSSNSD3 | |
| SCHEMBL3278151 | 0.78 | CALCRL (0.44) | CALCRLRAMP1CTSSNSD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737860-A1 | SELECTED CGRP-ANTAGONISTS, THEIR PREPARATION PROCESSES AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1722792-A1 | SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2006-11-22 | — | — | EP | claimed |
| WO-2005100352-A1 | SELECTED CGRP-ANTAGONISTS, THEIR PREPARATION PROCESSES AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-27 | — | — | WO | claimed |
| WO-2005084672-A1 | SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-15 | — | — | WO | claimed |
| EP-2108648-A1 | Selected CGRP antagonists, method for their manufacture and use as medicines | Boehringer Ingelheim International GmbH (DE) | 2009-10-14 | — | — | EP | disclosed |
| EP-1732917-B1 | SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-07-29 | — | — | EP | disclosed |
| EP-1737860-A1 | SELECTED CGRP-ANTAGONISTS, THEIR PREPARATION PROCESSES AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2007-01-03 | — | — | EP | disclosed |
| EP-1722792-A1 | SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005100352-A1 | SELECTED CGRP-ANTAGONISTS, THEIR PREPARATION PROCESSES AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-27 | — | — | WO | disclosed |
| WO-2005084672-A1 | SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-15 | — | — | WO | disclosed |
| EP-1558601-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004037811-A1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-06 | — | — | WO | disclosed |