Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | GRK3 | P35626 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984781 | 0.86 | FGFR1 (0.44) | YTHDC1LCKSCN9ADHODHCYP4F2 | |
| SCHEMBL3928183 | 0.81 | IGF1R (0.41) | LCKKDRCCNCCDK8GAA | |
| SCHEMBL4007933 | 0.81 | FGFR1 (0.37) | YTHDC1SCN9ADHODHCYP4F2CYP4A11 | |
| SCHEMBL4007939 | 0.81 | IGF1R (0.57) | KDR | |
| SCHEMBL3934716 | 0.80 | NR3C2 (0.44) | KDRROCK1 | |
| SCHEMBL62859 | 0.77 | DHODH (0.48) | DHODHCYP4F2CYP4A11ADCY10ROCK1 | |
| SCHEMBL2299253 | 0.76 | SCN9A (0.57) | LCKSCN9AKDRROCK1 | |
| SCHEMBL3980913 | 0.74 | FGFR1 (0.50) | KDR | |
| SCHEMBL3928820 | 0.74 | CLK4 (0.42) | KDRROCK1 | |
| SCHEMBL3926678 | 0.73 | IGF1R (0.50) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |