Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4077057 | 0.80 | GRM5 (0.69) | GRM5 | |
| SCHEMBL1821580 | 0.80 | GRM5 (1.00) | GRM5KCNMA1 | |
| SCHEMBL4070164 | 0.80 | GRM5 (1.00) | GRM5 | |
| SCHEMBL4069253 | 0.80 | GRM5 (1.00) | GRM5 | |
| SCHEMBL30879625 | 0.80 | GRM5 (1.00) | GRM5KCNMA1 | |
| SCHEMBL30255585 | 0.80 | GRM5 (1.00) | GRM5KCNMA1 | |
| SCHEMBL4071774 | 0.79 | GRM5 (0.78) | GRM5KCNMA1 | |
| SCHEMBL4072518 | 0.79 | GRM5 (0.77) | GRM5 | |
| SCHEMBL4069645 | 0.79 | GRM5 (0.70) | GRM5 | |
| SCHEMBL4069006 | 0.77 | GRM5 (0.70) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | claimed |
| EP-1611096-A4 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO INC (US) | 2007-08-29 | — | — | EP | claimed |
| US-20060235069-A1 | Benzamide modulators of metabotropic glutamate receptors | MERCK SHARP & DOHME CORP. | 2006-10-19 | — | — | US | claimed |
| JP-2006521358-A | — | — | 2006-09-21 | — | — | JP | claimed |
| EP-1611096-A2 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co. Inc. (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004087048-A2 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO. INC. (US) | 2004-10-14 | — | — | WO | claimed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-20060235069-A1 | Benzamide modulators of metabotropic glutamate receptors | MERCK SHARP & DOHME CORP. | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235069-A1 | Benzamide modulators of metabotropic glutamate receptors | GRM5, GRIK5, GRM2 | GRM5 1/4885ALDH1A1 2695/4885POLB 4325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.