Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.42 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.40 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963114 | 0.85 | CDK2 (0.53) | JAK2JAK1JAK3 | |
| SCHEMBL13883506 | 0.84 | TTK (0.43) | LRRK2PTK2JAK2EGFRJAK1 | |
| SCHEMBL3975590 | 0.83 | TTK (0.48) | PTK2JAK2EGFRJAK1JAK3 | |
| SCHEMBL3974456 | 0.82 | TTK (0.50) | PTK2JAK2EGFRJAK1JAK3 | |
| SCHEMBL13883495 | 0.81 | TTK (0.42) | PTK2JAK2EGFRJAK1JAK3 | |
| SCHEMBL3964230 | 0.81 | TTK (0.46) | PTK2JAK2EGFRJAK1JAK3 | |
| SCHEMBL3966549 | 0.80 | JAK2 (0.42) | LRRK2PTK2JAK2EGFRJAK1 | |
| SCHEMBL3973625 | 0.78 | TTK (0.55) | LRRK2PTK2JAK2EGFRJAK1 | |
| SCHEMBL3967615 | 0.77 | CDK2 (0.54) | JAK2JAK1JAK3BRD4 | |
| SCHEMBL4084023 | 0.76 | TTK (0.49) | LRRK2PTK2JAK2EGFRJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |