Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883506 | 0.84 | TTK (0.43) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL3975590 | 0.83 | TTK (0.48) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL3974456 | 0.82 | TTK (0.50) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL3964230 | 0.81 | TTK (0.46) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL4080704 | 0.80 | LRRK2 (0.46) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL3969198 | 0.79 | WEE1 (0.39) | JAK2JAK3JAK1BTKBRD4 | |
| SCHEMBL3971867 | 0.76 | TTK (0.46) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL3971546 | 0.76 | CDK2 (0.45) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL3970156 | 0.74 | TTK (0.61) | JAK2JAK3EGFRJAK1BTK | |
| SCHEMBL13883692 | 0.74 | JAK2 (0.41) | JAK2JAK3EGFRJAK1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |