⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31233794 | 0.92 | — | — | |
| SCHEMBL189108 | 0.74 | — | — | |
| SCHEMBL1200342 | 0.72 | — | — | |
| SCHEMBL30441147 | 0.72 | — | — | |
| SCHEMBL8065247 | 0.72 | — | — | |
| SCHEMBL23942057 | 0.72 | — | — | |
| SCHEMBL5487565 | 0.72 | — | — | |
| SCHEMBL9740934 | 0.69 | CTSL (0.35) | — | |
| SCHEMBL9740930 | 0.69 | CTSL (0.35) | — | |
| SCHEMBL17150816 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102936250-B | Fused bicyclic mtor inhibitors | OSI PHARM INC | 2014-07-09 | — | — | CN | disclosed |
| CN-102936250-A | Fused bicyclic mtor inhibitors | OSI PHARM INC | 2013-02-20 | — | — | CN | disclosed |
| US-20090215761-A1 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | CYLENE PHARMACEUTICALS, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| EP-1874731-A4 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | CYLENE PHARMACEUTICALS INC (US) | 2009-08-05 | — | — | EP | disclosed |
| CN-101316845-A | Fused bicyclic mTOR inhibitors | OSI PHARM INC (US) | 2008-12-03 | — | — | CN | disclosed |
| US-7402579-B2 | Quinobenzoxazine analogs and compositions | CYLENE PHARMACEUTICALS, INC. (US) | 2008-07-22 | — | — | US | disclosed |
| EP-1874731-A2 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | Cylene Pharmaceuticals, Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| US-20060264634-A1 | Quinobenzoxazine analogs and methods of using thereof | CYLENE PHARMACEUTICALS, INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006113509-A2 | QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF | CYLENE PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |