Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 4/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072498 | 0.91 | TSHR (0.52) | HPGDHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL4068547 | 0.87 | GRM5 (0.58) | HPGDHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL4078846 | 0.83 | HDAC1 (0.58) | HPGDHTTALDH1A1MEN1KMT2A | |
| SCHEMBL4078648 | 0.82 | POLB (0.44) | HPGDHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL4076114 | 0.81 | HDAC1 (0.52) | MEN1KMT2AGRM5HDAC1POLB | |
| SCHEMBL4072248 | 0.79 | POLB (0.47) | MEN1KMT2AGRM5HDAC1POLB | |
| SCHEMBL18669191 | 0.79 | KMT2A (0.62) | ALDH1A1MEN1KMT2ACASP3POLB | |
| SCHEMBL1308014 | 0.77 | HPGD (0.68) | HPGDHTTKDM4EALDH1A1KMT2A | |
| SCHEMBL18668934 | 0.74 | CA12 (0.55) | ALDH1A1MEN1KMT2ACASP3POLB | |
| SCHEMBL7895361 | 0.71 | CASP3 (0.53) | HTTALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | claimed |
| EP-1611096-A4 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO INC (US) | 2007-08-29 | — | — | EP | claimed |
| US-20060235069-A1 | Benzamide modulators of metabotropic glutamate receptors | MERCK SHARP & DOHME CORP. | 2006-10-19 | — | — | US | claimed |
| JP-2006521358-A | — | — | 2006-09-21 | — | — | JP | claimed |
| EP-1611096-A2 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co. Inc. (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004087048-A2 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO. INC. (US) | 2004-10-14 | — | — | WO | claimed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507836-B2 | Benzamide modulators of metabotropic glutamate receptors | MERCK & CO. INC. (US) | 2009-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235069-A1 | Benzamide modulators of metabotropic glutamate receptors | GRM5, GRIK5, GRM2 | HPGD 2829/4885HTT 541/4885KDM4E 1368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.