Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071550 | 0.82 | BRD4 (0.40) | ERN1KDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL4658279 | 0.77 | IL1B (0.50) | IL1BERN1KDM4EMAPTHTT | |
| SCHEMBL30028810 | 0.77 | KDM4E (0.62) | IL1BERN1KDM4EMAPTHTT | |
| SCHEMBL21075158 | 0.77 | KDM4E (0.62) | IL1BERN1KDM4EMAPTHTT | |
| SCHEMBL9837615 | 0.71 | MAPT (0.67) | ERN1KDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL5547974 | 0.70 | KDM4E (0.58) | IL1BERN1KDM4EMAPTHTT | |
| SCHEMBL14349104 | 0.69 | KDM4E (0.52) | IL1BERN1KDM4EMAPTHTT | |
| SCHEMBL27670919 | 0.69 | KDM4E (0.56) | IL1BERN1KDM4EMAPTHTT | |
| SCHEMBL1929285 | 0.69 | KDM4E (0.56) | IL1BERN1KDM4EMAPTHTT | |
| SCHEMBL12023179 | 0.68 | KDM4E (0.50) | IL1BERN1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084162-A2 | BICYCLIC TRIAZOLES AS PROTEIN KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008051808-A2 | BICYCLIC TRIAZOLES AS PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |