Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.76 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.76 |
| ▸ | BBOX1 | O75936 | 4/20 | 0.76 |
| ▸ | THRA | P10827 | 4/20 | 0.58 |
| ▸ | THRB | P10828 | 4/20 | 0.58 |
| ▸ | VEGFA | P15692 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | ASPH | Q12797 | 1/20 | 0.48 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25934724 | 0.86 | EGLN1 (0.80) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL29390250 | 0.86 | EGLN1 (1.00) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL522744 | 0.86 | EGLN1 (1.00) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL523982 | 0.86 | EGLN1 (0.55) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL28567789 | 0.84 | THRA (0.84) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL523025 | 0.84 | EGLN1 (0.67) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL522478 | 0.84 | EGLN1 (0.56) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL522875 | 0.82 | THRA (0.64) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL31028948 | 0.82 | THRA (0.64) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL12896198 | 0.81 | EGLN1 (0.80) | EGLN1FTOBBOX1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| US-6093730-A | AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-07-25 | — | — | US | disclosed |