Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16156539 | 0.91 | ALDH1A1 (0.45) | ALDH1A1KDM4ETDP1HTTCYP3A4 | |
| SCHEMBL18378212 | 0.90 | ALDH1A1 (0.45) | ALDH1A1KDM4ETDP1HTTCYP3A4 | |
| SCHEMBL18038900 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1HTTCYP3A4 | |
| SCHEMBL4573533 | 0.83 | MAPT (0.49) | ALDH1A1KDM4ETDP1CYP3A4NPC1 | |
| SCHEMBL2430950 | 0.83 | MAPT (0.52) | ALDH1A1KDM4ETDP1NPC1MEN1 | |
| SCHEMBL187593 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4ETDP1HTTCYP3A4 | |
| SCHEMBL25256040 | 0.82 | MAPT (0.43) | ALDH1A1KDM4ETDP1NPC1MEN1 | |
| SCHEMBL16156542 | 0.82 | ALDH1A1 (0.39) | ALDH1A1KDM4ETDP1CYP3A4MEN1 | |
| SCHEMBL17051112 | 0.81 | SMN1; SMN2 (0.39) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL4162450 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999988-B2 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2015-04-07 | — | — | US | disclosed |
| US-8999988-B2 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2015-04-07 | — | — | US | disclosed |
| US-20130302303-A1 | PROTEIN KINASE INHIBITORS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2013-11-14 | — | — | US | disclosed |
| US-20130302303-A1 | PROTEIN KINASE INHIBITORS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2013-11-14 | — | — | US | disclosed |
| US-8552018-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2013-10-08 | — | — | US | disclosed |
| US-8552018-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2013-10-08 | — | — | US | disclosed |
| US-20110212929-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2011-09-01 | — | — | US | disclosed |
| EP-1678166-B1 | PROTEIN KINASE INHIBITORS | UNIV ARIZONA (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090143399-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143399-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2009-06-04 | — | — | US | disclosed |
| US-20080051414-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-28 | — | — | US | disclosed |
| US-20080051414-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-28 | — | — | US | disclosed |
| US-7335662-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-26 | — | — | US | disclosed |
| EP-1888588-A2 | PROTEIN KINASE INHIBITORS | SuperGen, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| US-7326712-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326712-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326713-B2 | Substituted tricyclic compound as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-05 | — | — | US | disclosed |
| US-7312226-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312226-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2006116733-A2 | PROTEIN KINASE INHIBITORS | SUPERGEN, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130302303-A1 | PROTEIN KINASE INHIBITORS | CDK2, MAP3K1, MAP3K2 | ALDH1A1 2994/4885KDM4E 1499/4885TDP1 1918/4885 |
| US-20110212929-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | ALDH1A1 2994/4885KDM4E 1499/4885TDP1 1918/4885 |
| US-20080051414-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | ALDH1A1 2994/4885KDM4E 1499/4885TDP1 1918/4885 |
| US-20090143399-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | ALDH1A1 2994/4885KDM4E 1499/4885TDP1 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.