SCHEMBL4083602

SCHEMBL4083602

O=C1C=CC(=O)C(c2ccccc2)C1

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.53
GOPC Q9HD26 1/20 0.53
TSHR P16473 1/20 0.44
KMT2A Q03164 1/20 0.44
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
CTRC Q99895 1/20 0.41
NFKB1 P19838 2/20 0.40
NFKB2 Q00653 2/20 0.40
RELA Q04206 2/20 0.40
DDB1 Q16531 1/20 0.40
CRBN Q96SW2 1/20 0.40
ALDH1A1 P00352 1/20 0.39
CYP19A1 P11511 1/20 0.38
KDM4E B2RXH2 1/20 0.38
HSP90AA1 P07900 1/20 0.36
BRD4 O60885 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15657030 0.74 KMT2A (0.52) CFTRGOPCTSHRKMT2AGAA
SCHEMBL11512558 0.72 DDB1 (0.46) KMT2AMAPTDDB1CRBNALDH1A1
SCHEMBL10938628 0.71 MAPT (0.43) CFTRGOPCTSHRKMT2AGAA
SCHEMBL24625215 0.71 CFTR (0.59) CFTRGOPCTSHRKMT2AGAA
SCHEMBL4502876 0.71 CFTR (0.59) CFTRGOPCTSHRKMT2AGAA
SCHEMBL8713123 0.70 NFKB1 (0.48) CFTRGOPCTSHRKMT2AGAA
SCHEMBL5729305 0.69 CFTR (1.00) CFTRGOPCTSHRKMT2AGAA
SCHEMBL8738128 0.69 MAPT (0.54) KMT2AGAAMAPTALDH1A1KDM4E
SCHEMBL10435329 0.68 DDB1 (0.44) TSHRKMT2AGAAMAPTDDB1
SCHEMBL4275675 0.68 KDM1A (0.41) CFTRGOPCTSHRKMT2ADDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9732168-B2 Method of preparing ethylene polymers by controlled high pressure polymerization BASF SE (DE) 2017-08-15 US disclosed
US-20130150542-A1 Method Of Preparing Ethylene Polymers By Controlled High Pressure Polymerization BASF SE (DE) 2013-06-13 US disclosed
EP-2084227-A1 THERMOPLASTIC COMPOSITION, METHOD OF MANUFACTURE THEREOF, AND ARTICLES DERIVED THEREFROM Sabic Innovative Plastics IP B.V. (NL) 2009-08-05 EP disclosed
WO-2008063724-A1 THERMOPLASTIC COMPOSITION, METHOD OF MANUFACTURE THEREOF, AND ARTICLES DERIVED THEREFROM SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-05-29 WO disclosed
EP-1727837-A1 METHOD OF PREPARING ETHYLENE POLYMERS BY CONTROLLED HIGH PRESSURE POLYMERIZATION Ciba Geigy Specialty Chemicals Holding Inc. (CH) 2006-12-06 EP disclosed
WO-2005090419-A1 METHOD OF PREPARING ETHYLENE POLYMERS BY CONTROLLED HIGH PRESSURE POLYMERIZATION CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2005-09-29 WO disclosed
EP-1404729-A1 METHOD OF GRAFTING ETHYLENICALLY UNSATURATED CARBOXYLIC ACID DERIVATIVES ONTO THERMOPLASTIC POLYMERS USING HYDROXYLAMINE ESTERS Ciba SC Holding AG (CH) 2004-04-07 EP disclosed
EP-1282630-A1 HYDROXYLAMINE ESTERS AS POLYMERIZATION INITIATORS Ciba SC Holding AG (CH) 2003-02-12 EP disclosed
WO-2002092653-A1 METHOD OF GRAFTING ETHYLENICALLY UNSATURATED CARBOXYLIC ACID DERIVATIVES ONTO THERMOPLASTIC POLYMERS USING HYDROXYLAMINE ESTERS CIBA SPECIALITY CHEMICALS HOLDING INC. (CH) 2002-11-21 WO disclosed
WO-2001090113-A1 HYDROXYLAMINE ESTERS AS POLYMERIZATION INITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2001-11-29 WO disclosed
WO-1993004027-A1 PROCESS FOR THE PREPARATION OF PHENYLHYDROQUINONE EASTMAN KODAK COMPANY (US) 1993-03-04 WO disclosed
US-5185424-A THERMOTROPIC POLYESTERAMIDES HIMONT ITALIA S.R.L. (IT) 1993-02-09 US disclosed
EP-0433708-A2 Thermotropic polyesteramides HIMONT ITALIA S.r.l. (IT) 1991-06-26 EP disclosed
EP-0425341-A1 Aromatic thermotropic compositions and process for their preparation ELF ATOCHEM S.A. (FR) 1991-05-02 EP disclosed
EP-0408449-A1 Thermotropic semi-aliphatic copolyesteramides and process for their preparation ELF ATOCHEM S.A. (FR) 1991-01-16 EP disclosed
EP-0371995-A1 PROCESS FOR PRODUCING PHENYLHYDROQUINONES. EASTMAN KODAK CO (US) 1990-06-13 EP disclosed
EP-0351796-A2 Aromatic polyester carbonate and process for producing same NIPPON STEEL CORPORATION (JP) 1990-01-24 EP disclosed
EP-0346913-A2 Process for the synthesis of phenyl substituted aromatic diols HIMONT ITALIA S.r.l. (IT) 1989-12-20 EP disclosed
WO-1989000987-A1 PROCESS FOR PRODUCING PHENYLHYDROQUINONES EASTMAN KODAK COMPANY (US) 1989-02-09 WO disclosed
EP-0262900-A2 Anisotropic melt polyesters with improved glass transition temperature E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-04-06 EP disclosed