⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084383 | 0.84 | HSD11B1 (0.34) | — | |
| SCHEMBL4088772 | 0.84 | — | — | |
| SCHEMBL4083372 | 0.69 | HSD11B1 (0.34) | — | |
| SCHEMBL4088781 | 0.68 | HSD11B1 (0.36) | — | |
| SCHEMBL76826 | 0.63 | EPHX2 (0.34) | — | |
| SCHEMBL4089100 | 0.62 | — | — | |
| SCHEMBL4082735 | 0.60 | EPHX2 (0.33) | — | |
| SCHEMBL74761 | 0.60 | EPHX2 (0.39) | — | |
| SCHEMBL75019 | 0.57 | EPHX2 (0.33) | — | |
| SCHEMBL4084394 | 0.55 | EPHX2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |