Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10202013 | 0.88 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL10200609 | 0.88 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL4096836 | 0.88 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL4090412 | 0.88 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL4091135 | 0.88 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2718757 | 0.87 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL4092565 | 0.87 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL15437053 | 0.87 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL4097646 | 0.87 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL4099393 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |