Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10200609 | 1.00 | PIK3CD (0.45) | PIK3CDPIK3CGPIK3CBPIK3CAKDM4E | |
| SCHEMBL4090412 | 0.92 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL10202013 | 0.92 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL4091135 | 0.92 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL2717788 | 0.89 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL15437119 | 0.89 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL15437106 | 0.89 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL4085689 | 0.88 | PIK3CD (0.44) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL4101744 | 0.82 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 | |
| SCHEMBL4104277 | 0.82 | PIK3CD (0.49) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |