Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4085997 | 1.00 | HSD11B1 (0.42) | HSD11B1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL1971398 | 0.89 | HSD11B1 (0.45) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1972208 | 0.89 | HSD11B1 (0.45) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1972896 | 0.88 | HSD11B1 (0.48) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1973243 | 0.88 | HSD11B1 (0.48) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1973695 | 0.88 | HSD11B1 (0.48) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1972958 | 0.88 | HSD11B1 (0.46) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1973245 | 0.88 | HSD11B1 (0.48) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1972748 | 0.88 | HSD11B1 (0.46) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1971420 | 0.86 | HSD11B1 (0.43) | HSD11B1MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203737-A1 | Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors | ADDEX PHARMA SA (CH) | 2009-08-13 | — | — | US | claimed |
| US-20090203737-A1 | Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors | ADDEX PHARMA SA (CH) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203737-A1 | Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors | GRM5, GRIK5, GRM2 | HSD11B1 3461/4885CYP11B1 1834/4885CYP11B2 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.