Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 9/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.45 |
| ▸ | TEK | Q02763 | 2/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 6/20 | 0.42 |
| ▸ | MTOR | P42345 | 6/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086058 | 0.90 | NTRK1 (0.50) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL4076485 | 0.89 | NTRK1 (0.64) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL4078414 | 0.85 | NTRK1 (0.67) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL1939947 | 0.84 | PDGFRB (0.62) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL4081490 | 0.84 | PDPK1 (0.55) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL4080442 | 0.83 | NTRK1 (0.58) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL1942841 | 0.81 | EIF2AK3 (0.53) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL4079511 | 0.80 | NTRK1 (0.49) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL1941376 | 0.79 | EIF2AK3 (0.51) | NTRK1NTRK2NTRK3KCNH2PDPK1 | |
| SCHEMBL4086560 | 0.79 | NTRK1 (0.64) | NTRK1NTRK2NTRK3KCNH2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595325-B2 | Substituted pyrrolo[2,3-d]pyrimidine derivatives useful in cancer treatment | PFIZER INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-20060035912-A1 | Pyrrolopyrimidine derivatives useful in cancer treatment | PFIZER INC | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035912-A1 | Pyrrolopyrimidine derivatives useful in cancer treatment | TP53, DPYD, CCNT1 | NTRK1 3916/4885NTRK2 4246/4885NTRK3 2158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.