Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.55 |
| ▸ | CA2 | P00918 | 10/20 | 0.55 |
| ▸ | CA9 | Q16790 | 8/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.55 |
| ▸ | CA3 | P07451 | 2/20 | 0.55 |
| ▸ | CA4 | P22748 | 2/20 | 0.55 |
| ▸ | CA6 | P23280 | 2/20 | 0.55 |
| ▸ | CA5A | P35218 | 2/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL8488971 | 0.98 | CA1 (0.57) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL26120658 | 0.98 | CA1 (0.57) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL4442960 | 0.96 | CA1 (0.55) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL28334623 | 0.96 | CA1 (0.55) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL20975510 | 0.96 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL17457773 | 0.96 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL5323895 | 0.96 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL10715883 | 0.96 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL11518304 | 0.96 | CA1 (0.59) | CA1CA2CA9CA12CA7 | |
| Sulfuric Acid SCHEMBL28593793 | 0.94 | CA1 (0.53) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263558-B2 | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins | ABBOTT LABORATORIES (US) | 2012-09-11 | — | — | US | disclosed |
| US-20090214515-A1 | METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2009-08-27 | — | — | US | disclosed |
| EP-1963363-A2 | METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS | Abbott Laboratories (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007064917-A2 | METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS | ABBOTT LABORATORIES (US) | 2007-06-07 | — | — | WO | disclosed |