Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21883942 | 0.73 | — | — | |
| SCHEMBL9846854 | 0.68 | ESR1 (0.42) | KDM4ELMNAMAPTHTT | |
| SCHEMBL5244300 | 0.68 | TAAR1 (0.38) | SLC6A2TAAR1CYP3A4HTT | |
| SCHEMBL12575109 | 0.66 | EGFR (0.38) | CYP3A4MAPT | |
| SCHEMBL20985607 | 0.66 | KMT2A (0.38) | SLC6A2TAAR1CYP3A4KDM4EHTT | |
| SCHEMBL1836277 | 0.65 | TSHR (0.38) | SLC6A2TAAR1CYP3A4KDM4EHTT | |
| SCHEMBL2336960 | 0.64 | CYP3A4 (0.69) | CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL6599022 | 0.64 | CYP19A1 (0.39) | SLC6A2TAAR1CYP3A4KDM4EHTT | |
| SCHEMBL29014292 | 0.64 | CYP2E1 (0.37) | CYP2E1CYP3A4CYP2A6KDM4EMAPT | |
| SCHEMBL6625810 | 0.64 | SLC6A2 (0.75) | SLC6A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |