Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087976 | 1.00 | HSD11B1 (0.40) | HSD11B1NOTUMUCHL1USP30KMT2A | |
| SCHEMBL2073114 | 0.93 | HSD11B1 (0.45) | HSD11B1NOTUMUCHL1USP30POLB | |
| SCHEMBL2073118 | 0.93 | HSD11B1 (0.45) | HSD11B1NOTUMUCHL1USP30POLB | |
| SCHEMBL2071425 | 0.93 | HSD11B1 (0.45) | HSD11B1NOTUMKMT2AMEN1POLB | |
| SCHEMBL2071427 | 0.93 | HSD11B1 (0.45) | HSD11B1NOTUMKMT2AMEN1POLB | |
| SCHEMBL2071202 | 0.81 | HSD11B1 (0.45) | HSD11B1NOTUMPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2071794 | 0.81 | HSD11B1 (0.45) | HSD11B1NOTUMUCHL1USP30KMT2A | |
| SCHEMBL2071793 | 0.81 | HSD11B1 (0.45) | HSD11B1NOTUMUCHL1USP30KMT2A | |
| SCHEMBL2071200 | 0.81 | HSD11B1 (0.45) | HSD11B1NOTUMPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2072978 | 0.80 | PDE4B (0.48) | HSD11B1NOTUMKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046791-A2 | UREA DERIVATIVES OF TROPANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | Sanofi-Aventis (FR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008000951-A2 | UREA DERIVATIVES OF TROPANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2008-01-03 | — | — | WO | disclosed |