Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16804661 | 0.81 | PLA2G4B (0.55) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL16804658 | 0.81 | MRGPRX4 (0.51) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL40891 | 0.81 | MRGPRX4 (0.43) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL40246 | 0.79 | CYP4F2 (0.49) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL15444416 | 0.76 | KDM4E (0.48) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL27487853 | 0.74 | CYP4F2 (0.47) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL2719733 | 0.72 | CYP4F2 (0.41) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL2722077 | 0.72 | CYP4F2 (0.41) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL40158 | 0.72 | CYP4F2 (0.41) | MRGPRX4TP53PKMNFKB1NFKB2 | |
| SCHEMBL40210 | 0.72 | CYP4F2 (0.41) | MRGPRX4TP53PKMNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |