Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092075 | 0.81 | USP2 (0.40) | ALDH1A1L3MBTL1LMNAMAPTUSP2 | |
| SCHEMBL17380950 | 0.77 | CES2 (0.46) | POLBRECQLKMT2A | |
| SCHEMBL22241276 | 0.77 | CES2 (0.46) | POLBRECQLKMT2A | |
| SCHEMBL2718388 | 0.76 | POLB (0.32) | ALDH1A1L3MBTL1LMNAPOLBMAPT | |
| SCHEMBL2718384 | 0.76 | POLB (0.32) | ALDH1A1L3MBTL1LMNAPOLBMAPT | |
| SCHEMBL31473198 | 0.75 | CES2 (0.34) | ALDH1A1L3MBTL1LMNAPOLBMAPT | |
| SCHEMBL22201767 | 0.67 | HDAC3 (0.41) | ALDH1A1MAPTKDM4ETSHR | |
| SCHEMBL17503145 | 0.67 | HPGD (0.43) | ALDH1A1L3MBTL1LMNAPOLBMAPT | |
| SCHEMBL17539208 | 0.67 | HPGD (0.43) | ALDH1A1L3MBTL1LMNAPOLBMAPT | |
| SCHEMBL17503146 | 0.67 | HPGD (0.43) | ALDH1A1L3MBTL1LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |