Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | SRC | P12931 | 18/20 | 0.69 |
| ▸ | ABL1 | P00519 | 15/20 | 0.69 |
| ▸ | EGFR | P00533 | 11/20 | 0.69 |
| ▸ | KDR | P35968 | 11/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.69 |
| ▸ | HCK | P08631 | 10/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.69 |
| ▸ | PRKDC | P78527 | 10/20 | 0.69 |
| ▸ | MTOR | P42345 | 10/20 | 0.69 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.69 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.69 |
| ▸ | BTK | Q06187 | 3/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13019808 | 0.89 | SMN1; SMN2 (0.75) | SMN1; SMN2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL409372 | 0.87 | SRC (0.72) | SMN1; SMN2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL14086495 | 0.85 | PIK3CD (0.71) | SMN1; SMN2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL130466 | 0.84 | PIK3CD (0.76) | SRCABL1EGFRKDRPIK3CD | |
| SCHEMBL14617301 | 0.84 | SRC (0.89) | SMN1; SMN2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL3695039 | 0.83 | KDM4E (1.00) | SMN1; SMN2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL5620074 | 0.83 | SRC (0.78) | SMN1; SMN2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL18874474 | 0.81 | PIK3CD (0.72) | SRCABL1EGFRKDRPIK3CD | |
| SCHEMBL3607753 | 0.81 | PIK3CD (1.00) | SRCABL1EGFRKDRPIK3CD | |
| SCHEMBL408497 | 0.81 | SRC (0.76) | SMN1; SMN2KDM4EALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168151-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-16 | — | — | US | disclosed |
| US-20160168151-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-16 | — | — | US | disclosed |
| US-20150031881-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-01-29 | — | — | US | disclosed |
| US-20150031881-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-01-29 | — | — | US | disclosed |
| US-20120065154-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065154-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-03-15 | — | — | US | disclosed |
| US-20090181988-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | US | disclosed |
| US-20090181988-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | US | disclosed |
| US-7429596-B2 | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168151-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, DHODH, DLD | SMN1; SMN2 3483/4885KDM4E 2263/4885ALDH1A1 198/4885 |
| US-20150031881-A1 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, DHODH, DLD | SMN1; SMN2 3483/4885KDM4E 2263/4885ALDH1A1 198/4885 |
| US-20090181988-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | DPYD, DHODH, DLD | SMN1; SMN2 3483/4885KDM4E 2263/4885ALDH1A1 198/4885 |
| US-20120065154-A1 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof | DPYD, DHODH, DLD | SMN1; SMN2 3483/4885KDM4E 2263/4885ALDH1A1 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.