Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rimantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.95 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.95 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rimantadine SCHEMBL28108817 | 1.00 | MAPT (1.00) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL4366035 | 1.00 | MAPT (1.00) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL29908943 | 0.97 | SLC22A2 (1.00) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL2982 | 0.97 | SLC22A2 (1.00) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL15532385 | 0.97 | SLC22A2 (1.00) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL20409367 | 0.97 | SLC22A2 (1.00) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL2981 | 0.97 | SLC22A2 (1.00) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL14973619 | 0.92 | SLC22A2 (0.90) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL3719331 | 0.88 | SLC22A2 (0.82) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 | |
| Rimantadine SCHEMBL4667033 | 0.88 | SLC22A2 (0.82) | MAPTSLC22A2SLC47A1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3549 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026043843-A1 | TETRAHYDROPYRIMIDINE (THP) IONIZABLE LIPIDS FOR EFFICIENT MRNA DELIVERY | THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, (US) | 2026-02-26 | — | — | WO | claimed |
| US-12337065-B2 | Compositions for treating viral infections and methods for same | ACCESS TO ADVANCED HEALTH INSTITUTE (US) | 2025-06-24 | — | — | US | claimed |
| CN-116297965-B | Method for simultaneously measuring 18 illegally added antiviral drugs | 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） | 2025-05-06 | — | — | CN | claimed |
| CN-119470716-A | Method for detecting dissolution rate of rimantadine hydrochloride preparation | 金陵药业股份有限公司 | 2025-02-18 | — | — | CN | claimed |
| CN-116606193-B | Synthesis method of rimantadine hydrochloride | 山东轩鸿生物医药有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119086797-A | Method for measuring residual quantity of 16 veterinary drugs in animal-derived food by adopting QuEChERS combined with high performance liquid chromatography tandem mass spectrometry | 福建省微生物研究所 | 2024-12-06 | — | — | CN | claimed |
| WO-2024215771-A1 | SUBSTITUTED PHENYL ETHYNYL PYRIMIDINES AS POTENT INHIBITORS OF ALPHAVIRUSES | SOUTHERN RESEARCH INSTITUTE (US) | 2024-10-17 | — | — | WO | claimed |
| CN-118667344-A | Temperature-sensitive injectable self-healing supermolecule hydrogel based on P (MVE-alt-MA) and preparation method thereof | 中国石油化工股份有限公司 | 2024-09-20 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-117677631-A | Novel compositions and methods for treating coronavirus infections | 昆士兰医学研究所理事会 | 2024-03-08 | — | — | CN | claimed |
| EP-0968013-A1 | COATED IMPLANTABLE MEDICAL DEVICE | Cook Incorporated (US) | 2000-01-05 | — | — | EP | claimed |
| US-5873904-A | Silver implantable medical device | COOK INCORPORATED (US) | 1999-02-23 | — | — | US | claimed |
| WO-1998036784-A1 | COATED IMPLANTABLE MEDICAL DEVICE | COOK INCORPORATED (US) | 1998-08-27 | — | — | WO | claimed |
| WO-1998017331-A1 | SILVER IMPLANTABLE MEDICAL DEVICE | COOK INCORPORATED (US) | 1998-04-30 | — | — | WO | claimed |
| EP-0747069-A2 | Implantable medical device | Cook Incorporated (US) | 1996-12-11 | — | — | EP | claimed |
| US-5357636-A | Flexible protective medical gloves and methods for their use | DRESDNER JR KARL P (US) | 1994-10-25 | — | — | US | claimed |
| EP-0596935-A1 | ANTIVIRAL PHARMACEUTICAL COMPOSITIONS FOR VAGINAL ADMINISTRATION. | L C PHARCHEM LTD (CY) | 1994-05-18 | — | — | EP | claimed |
| CN-1082894-A | The anti-viral pharmaceutical compositions of vagina administration | L C PHARCHEM LTD (CY) | 1994-03-02 | — | — | CN | claimed |
| WO-1993002662-A1 | ANTIVIRAL PHARMACEUTICAL COMPOSITIONS FOR VAGINAL ADMINISTRATION | L.C. PHARCHEM LTD. (CY) | 1993-02-18 | — | — | WO | claimed |
| EP-0178668-A2 | Process for preparing rimantadine | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-04-23 | — | — | EP | claimed |