Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rimantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 2/20 | 0.82 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rimantadine SCHEMBL1074987 | 1.00 | SLC22A2 (0.82) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL2981 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL15532385 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL29908943 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL20409367 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL2982 | 0.91 | SLC22A2 (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL40906 | 0.88 | MAPT (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL4366035 | 0.88 | MAPT (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL28108817 | 0.88 | MAPT (1.00) | SLC22A2SLC47A1MAPTGRIN1GRIN2A | |
| Rimantadine SCHEMBL14973619 | 0.86 | SLC22A2 (0.90) | SLC22A2SLC47A1MAPTGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010095041-A2 | COMPOSITIONS, METHODS, AND KITS FOR TREATING INFLUENZA VIRAL INFECTIONS | EXCRX (SINGAPORE) PTE.LTD. (SG) | 2010-08-26 | — | — | WO | disclosed |