Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 10/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 6/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084115 | 0.88 | MAP3K12 (0.38) | MAPK14MAP3K12SYKPRKD1PRKD2 | |
| SCHEMBL13708533 | 0.88 | MAP3K12 (0.38) | MAPK14MAP3K12SYKPRKD1PRKD2 | |
| SCHEMBL4090456 | 0.85 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4089262 | 0.85 | MAPK14 (0.41) | MAPK14MAP3K12MAPK13MAPK12MAPK11 | |
| SCHEMBL4089265 | 0.85 | MAPK14 (0.41) | MAPK14MAP3K12MAPK13MAPK12MAPK11 | |
| SCHEMBL4094684 | 0.85 | MAPK14 (0.41) | MAPK14MAP3K12MAPK13MAPK12MAPK11 | |
| SCHEMBL13708531 | 0.85 | MAPK14 (0.41) | MAPK14MAP3K12MAPK13MAPK12MAPK11 | |
| SCHEMBL4089862 | 0.85 | MAPK14 (0.41) | MAPK14MAP3K12MAPK13MAPK12MAPK11 | |
| SCHEMBL13708532 | 0.85 | MAPK14 (0.41) | MAPK14MAP3K12MAPK13MAPK12MAPK11 | |
| SCHEMBL4094440 | 0.85 | MAPK14 (0.40) | MAPK14PRKD1PRKD2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182072-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-08-18 | — | — | US | claimed |
| US-20090149468-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149468-A1 | Substituted heterocyclic compounds and methods of use | HLA-DRB1, PRKDC, NFATC1 | MAPK14 1220/4885MAP3K12 397/4885SYK 240/4885 |
| US-20050182072-A1 | Substituted heterocyclic compounds and methods of use | HLA-DRB1, PRKDC, NFATC1 | MAPK14 964/4885MAP3K12 285/4885SYK 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.