Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Beta Carotene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.89 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.89 |
| ▸ | LMNA | P02545 | 2/20 | 0.89 |
| ▸ | DRD3 | P35462 | 2/20 | 0.89 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.89 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.89 |
| ▸ | MAPT | P10636 | 7/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.85 |
| ▸ | RXRA | P19793 | 5/20 | 0.85 |
| ▸ | RARA | P10276 | 4/20 | 0.85 |
| ▸ | RARB | P10826 | 4/20 | 0.85 |
| ▸ | RARG | P13631 | 4/20 | 0.85 |
| ▸ | APP | P05067 | 4/20 | 0.85 |
| ▸ | SNCA | P37840 | 4/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.85 |
| ▸ | RXRB | P28702 | 2/20 | 0.85 |
| ▸ | RXRG | P48443 | 2/20 | 0.85 |
| ▸ | RORC | P51449 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Beta Carotene SCHEMBL6650927 | 0.96 | ALDH1A1 (0.92) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL135090 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL29636150 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL29445419 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL6151 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL15066330 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL5316237 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL2300399 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL20996197 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 | |
| Beta Carotene SCHEMBL29360574 | 0.94 | ALDH1A1 (1.00) | ALDH1A1PTGS1LMNADRD3SLCO1B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090220640-A1 | Method of Supplementing Animals with Carotenoids by Drinking Water | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2009-09-03 | — | — | US | disclosed |