Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 4/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | CBFB | Q13951 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10199790 | 0.91 | GRM5 (0.40) | NPC1KDM4EGRM5LMNARAB9A | |
| SCHEMBL2718744 | 0.91 | GRM5 (0.40) | NPC1KDM4EGRM5LMNARAB9A | |
| SCHEMBL4097964 | 0.78 | PIK3CD (0.47) | — | |
| SCHEMBL2720782 | 0.78 | CCR1 (0.38) | GRM5CBFBKMT2ACCR1CCR5 | |
| SCHEMBL2718747 | 0.78 | FFAR1 (0.36) | NPC1KDM4EGRM5HTTRAB9A | |
| SCHEMBL2718021 | 0.75 | PIK3CD (0.61) | — | |
| SCHEMBL12319817 | 0.75 | KDM4E (0.52) | NPC1KDM4EGRM5METAP1HTT | |
| SCHEMBL12320145 | 0.70 | KDM4E (0.47) | NPC1KDM4EGRM5METAP1HTT | |
| SCHEMBL2718686 | 0.69 | PIK3CD (0.45) | METAP1METAP2CBFBLMNAFFAR1 | |
| SCHEMBL19105582 | 0.69 | KDM4E (0.48) | NPC1KDM4EGRM5METAP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |