SCHEMBL409549

SCHEMBL409549

CC(C)(C)c1ncnc2c1c(C(C)(C)C)nn2C(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 16/20 0.47
ABL1 P00519 10/20 0.47
KDM4E B2RXH2 4/20 0.47
ALDH1A1 P00352 4/20 0.47
HTT P42858 4/20 0.47
RIPK2 O43353 4/20 0.47
FYN P06241 4/20 0.47
EGFR P00533 3/20 0.47
KDR P35968 3/20 0.47
LMNA P02545 3/20 0.47
PRKACA P17612 3/20 0.47
CSNK1A1 P48729 3/20 0.47
MAPK14 Q16539 3/20 0.47
CSNK1D P48730 3/20 0.47
PRKD3 O94806 3/20 0.47
CSK P41240 3/20 0.47
PRKD2 Q9BZL6 3/20 0.47
LCK P06239 2/20 0.47
YES1 P07947 2/20 0.47
LYN P07948 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15929311 0.84 SRC (0.61) SRCABL1KDM4EALDH1A1HTT
SCHEMBL22388667 0.82 SRC (0.40) SRCABL1KDM4EALDH1A1HTT
SCHEMBL10457496 0.82 SRC (0.42) SRCABL1KDM4EALDH1A1HTT
SCHEMBL10261882 0.82 SRC (0.41) SRCABL1KDM4EALDH1A1HTT
SCHEMBL15101790 0.82 SRC (0.40) SRCABL1KDM4EALDH1A1HTT
SCHEMBL19303475 0.79 PIK3CD (0.36) SRCABL1KDM4EALDH1A1HTT
SCHEMBL22002210 0.75 SRC (0.35) SRCABL1KDM4EALDH1A1HTT
SCHEMBL14584045 0.71 SRC (0.33) SRCABL1KDM4EALDH1A1HTT
SCHEMBL4928772 0.71 KDM4E (0.44) SRCABL1KDM4EALDH1A1HTT
SCHEMBL4923676 0.71 SRC (0.44) SRCABL1KDM4EALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240065971-A1 METHODS OF TREATING ABC-DLBCL USING INHIBITORS OF BRUTONS TYROSINE KINASE PHARMACYCLICS LLC (US) 2024-02-29 US disclosed
US-20230248730-A1 USE OF INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) PHARMACYCLICS LLC (US) 2023-08-10 US disclosed
US-11672803-B2 Use of inhibitors of Brutons tyrosine kinase (Btk) PHARMACYCLICS LLC (US) 2023-06-13 US disclosed
US-20210361657-A1 USE OF INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) PHARMACYCLICS LLC (US) 2021-11-25 US disclosed
US-20180193345-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS PHARMACYCLICS LLC 2018-07-12 US disclosed
US-10016435-B2 Use of inhibitors of Bruton's tyrosine kinase (Btk) PHARMACYCLICS LLC (US) 2018-07-10 US disclosed
US-10016435-B2 Use of inhibitors of Bruton's tyrosine kinase (Btk) PHARMACYCLICS LLC (US) 2018-07-10 US disclosed
US-10004745-B2 Use of inhibitors of Bruton'S tyrosine kinase (Btk) PHARMACYCLICS LLC (US) 2018-06-26 US disclosed
US-20180036313-A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) PHARMACYCLICS, INC. 2018-02-08 US disclosed
US-20180036313-A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) PHARMACYCLICS, INC. 2018-02-08 US disclosed
US-20120178753-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2012-07-12 US disclosed
US-20120165328-A1 INHIBITORS OF B LYMPHOCYTE KINASE PHARMACYCLICS, INC. (US) 2012-06-28 US disclosed
US-20120100138-A1 THE USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) PHARMACYCLICS, INC. (US) 2012-04-26 US disclosed
US-20120101113-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2012-04-26 US disclosed
US-20120101114-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2012-04-26 US disclosed
US-20120087915-A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) PHARMACYCLICS, INC. (US) 2012-04-12 US disclosed
US-20120071497-A1 METHODS OF TREATING ABC-DLBCL USING INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2012-03-22 US disclosed
US-20120065201-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS, INC. (US) 2012-03-15 US disclosed
US-20110224235-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS PHARMACYCLICS, INC. (US) 2011-09-15 US disclosed
US-20100254905-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE PHARMACYCLICS LLC 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (18 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120178753-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, ABL2 SRC 17/4885ABL1 1/4885KDM4E 902/4885
US-20120165328-A1 INHIBITORS OF B LYMPHOCYTE KINASE BLK, DCK, LTK SRC 287/4885ABL1 60/4885KDM4E 697/4885
US-10016435-B2 Use of inhibitors of Bruton's tyrosine kinase (Btk) BTK, SYK, LYN SRC 17/4885ABL1 8/4885KDM4E 2459/4885
US-20180036313-A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) BTK, SYK, LYN SRC 17/4885ABL1 8/4885KDM4E 2459/4885
US-20210361657-A1 USE OF INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) BTK, LYN, SYK SRC 11/4885ABL1 4/4885KDM4E 1786/4885
US-20180193345-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS BTK, ABL1, LYN SRC 6/4885ABL1 2/4885KDM4E 725/4885
US-20120071497-A1 METHODS OF TREATING ABC-DLBCL USING INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, BCL6, BCL6B SRC 33/4885ABL1 19/4885KDM4E 1288/4885
US-20240065971-A1 METHODS OF TREATING ABC-DLBCL USING INHIBITORS OF BRUTONS TYROSINE KINASE BTK, BCL6, BCL6B SRC 42/4885ABL1 27/4885KDM4E 1341/4885
US-10004745-B2 Use of inhibitors of Bruton'S tyrosine kinase (Btk) BTK, SYK, LYN SRC 17/4885ABL1 8/4885KDM4E 2459/4885
US-20120101114-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, ABL2 SRC 17/4885ABL1 1/4885KDM4E 902/4885
US-20100254905-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, ABL2 SRC 17/4885ABL1 1/4885KDM4E 902/4885
US-20230248730-A1 USE OF INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) BTK, LYN, SYK SRC 21/4885ABL1 9/4885KDM4E 2333/4885
US-11672803-B2 Use of inhibitors of Brutons tyrosine kinase (Btk) BTK, LYN, SYK SRC 21/4885ABL1 9/4885KDM4E 2333/4885
US-20120101113-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, ABL2 SRC 17/4885ABL1 1/4885KDM4E 902/4885
US-20110224235-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS BTK, ABL1, LYN SRC 6/4885ABL1 2/4885KDM4E 725/4885
US-20120087915-A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) BTK, SYK, LYN SRC 17/4885ABL1 8/4885KDM4E 2459/4885
US-20120065201-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE ABL1, BTK, ABL2 SRC 17/4885ABL1 1/4885KDM4E 902/4885
US-20120100138-A1 THE USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) BTK, SYK, LYN SRC 20/4885ABL1 13/4885KDM4E 2440/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.