Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olsalazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.63 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | BLVRB | P30043 | 2/20 | 0.66 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | THRB | P10828 | 3/20 | 0.63 |
| ▸ | RECQL | P46063 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CASP1 | P29466 | 2/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olsalazine SCHEMBL15201080 | 0.91 | MEN1 (0.79) | MEN1KMT2AKDRBLVRBPDE4A | |
| Olsalazine SCHEMBL8703147 | 0.91 | MEN1 (0.79) | MEN1KMT2AKDRBLVRBPDE4A | |
| Olsalazine SCHEMBL1830807 | 0.91 | MEN1 (0.79) | MEN1KMT2AKDRBLVRBPDE4A | |
| SCHEMBL1614891 | 0.88 | TDP1 (0.57) | MEN1KMT2AKDRBLVRBPDE4A | |
| Olsalazine SCHEMBL28241744 | 0.85 | TDP1 (0.54) | MEN1KMT2AKDRBLVRBPDE4A | |
| SCHEMBL4326140 | 0.85 | MEN1 (0.79) | MEN1KMT2AKDRBLVRBPDE4A | |
| SCHEMBL4326144 | 0.85 | MEN1 (0.79) | MEN1KMT2AKDRBLVRBPDE4A | |
| Olsalazine SCHEMBL29767 | 0.84 | MEN1 (0.66) | MEN1KMT2AKDRBLVRBPDE4A | |
| Olsalazine SCHEMBL3476110 | 0.84 | MEN1 (0.66) | MEN1KMT2AKDRBLVRBPDE4A | |
| Olsalazine SCHEMBL29454399 | 0.84 | MEN1 (0.66) | MEN1KMT2AKDRBLVRBPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023805-A1 | METHOD OF ADMINISTRATION | MARRAST ANNE CLAIRE | 2009-01-22 | — | — | US | disclosed |
| EP-1933835-A1 | PHARMACEUTICALLY ACTIVE TETRAHYDRO-PYRROLO[1,2-B]ISOTHIAZOLE 1,1-DIOXIDES | Novartis AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007039616-A1 | PHARMACEUTICALLY ACTIVE TETRAHYDRO-PYRROLO[1,2-B]ISOTHIAZOLE 1,1-DIOXIDES | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |