Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olsalazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.76 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.65 |
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.79 |
| ▸ | KDR | P35968 | 2/20 | 0.79 |
| ▸ | PDE4A | P27815 | 1/20 | 0.79 |
| ▸ | BLVRB | P30043 | 1/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | THRB | P10828 | 3/20 | 0.76 |
| ▸ | RECQL | P46063 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | TNF | P01375 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olsalazine SCHEMBL1830807 | 1.00 | MEN1 (0.79) | MEN1KMT2AKDRPDE4ABLVRB | |
| SCHEMBL4326144 | 0.93 | MEN1 (0.79) | MEN1KMT2AKDRPDE4ABLVRB | |
| SCHEMBL4326140 | 0.93 | MEN1 (0.79) | MEN1KMT2AKDRPDE4ABLVRB | |
| Olsalazine SCHEMBL4096909 | 0.91 | MEN1 (0.66) | MEN1KMT2AKDRPDE4ABLVRB | |
| Olsalazine SCHEMBL28125721 | 0.90 | MEN1 (0.74) | MEN1KMT2AKDRPDE4ABLVRB | |
| Olsalazine SCHEMBL28125720 | 0.90 | MEN1 (0.74) | MEN1KMT2AKDRPDE4ABLVRB | |
| Olsalazine SCHEMBL29385751 | 0.89 | MEN1 (1.00) | MEN1KMT2AKDRPDE4ABLVRB | |
| Olsalazine SCHEMBL25118 | 0.89 | MEN1 (1.00) | MEN1KMT2AKDRPDE4ABLVRB | |
| Olsalazine SCHEMBL25119 | 0.89 | MEN1 (1.00) | MEN1KMT2AKDRPDE4ABLVRB | |
| Olsalazine SCHEMBL29378994 | 0.89 | MEN1 (1.00) | MEN1KMT2AKDRPDE4ABLVRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998022114-A1 | A METHOD FOR PROMOTING TISSUE REPAIR | DUMEX-ALPHARMA A/S (DK) | 1998-05-28 | — | — | WO | disclosed |