Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 15/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4101616 | 1.00 | PARP1 (0.40) | PARP1MAPK8HDAC1PLK1GPR119 | |
| SCHEMBL4098948 | 1.00 | PARP1 (0.40) | PARP1MAPK8HDAC1PLK1GPR119 | |
| SCHEMBL6533999 | 0.93 | PLK1 (0.42) | PARP1MAPK8HDAC1PLK1 | |
| SCHEMBL4089777 | 0.93 | PLK1 (0.43) | PARP1MAPK8HDAC1PLK1 | |
| SCHEMBL5986376 | 0.85 | PARP1 (0.42) | PARP1MAPK8HDAC1GPR119SPR | |
| SCHEMBL4094807 | 0.83 | PLK1 (0.42) | PLK1 | |
| SCHEMBL4084908 | 0.83 | PLK1 (0.42) | PLK1 | |
| SCHEMBL4094651 | 0.83 | PLK1 (0.42) | PLK1 | |
| SCHEMBL4088559 | 0.83 | PLK1 (0.46) | PLK1 | |
| SCHEMBL4089886 | 0.82 | ITGAL (0.40) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582631-B2 | Paget's disease; muscular disorders; cardiovascular disorders; antiinflamamtory agents; antidiabetic agents; autoimmune disease; leukemia | AMGEN INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-20090149468-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20050182072-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149468-A1 | Substituted heterocyclic compounds and methods of use | HLA-DRB1, PRKDC, NFATC1 | PARP1 1569/4885MAPK8 1645/4885HDAC1 1562/4885 |
| US-20050182072-A1 | Substituted heterocyclic compounds and methods of use | HLA-DRB1, PRKDC, NFATC1 | PARP1 2042/4885MAPK8 1971/4885HDAC1 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.