Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | LOX | P28300 | 4/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4115551 | 0.89 | BRAF (0.50) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL5115943 | 0.85 | BRAF (0.44) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL3984127 | 0.83 | GPR52 (0.52) | BRAFKDRNR3C2MAPK14 | |
| SCHEMBL4293095 | 0.82 | GRM5 (0.49) | BRAFCA1CA2CA7CA9 | |
| SCHEMBL5119964 | 0.81 | NPC1 (0.55) | BRAFLOXLOXL2MAPTNR3C2 | |
| SCHEMBL3991944 | 0.80 | GRM5 (0.58) | NPC1RAB9A | |
| SCHEMBL3986152 | 0.80 | GRM5 (0.56) | BRAFLOXLOXL2CA1CA2 | |
| SCHEMBL4111366 | 0.79 | BRAF (0.56) | BRAFKDRRAF1MAPK14 | |
| SCHEMBL3986272 | 0.77 | NR3C2 (0.45) | BRAFKDRRAF1CA1CA2 | |
| SCHEMBL3994618 | 0.77 | RAF1 (0.54) | BRAFKDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061761-A1 | PHENETHYLAMIDE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | Millennium Pharmaceuticals, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008030448-A1 | PHENETHYLAMIDE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | WO | disclosed |