Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12942174 | 0.84 | MAPK1 (0.52) | MAPK1 | |
| SCHEMBL12941959 | 0.84 | HCAR3 (0.38) | HCAR3CHEK1CSNK2A1MAPK1CSNK2A2 | |
| SCHEMBL4100544 | 0.84 | HCAR3 (0.38) | HCAR3CHEK1OPRK1CSNK2A1CSNK2A2 | |
| SCHEMBL8234399 | 0.81 | SMYD3 (0.51) | SYK | |
| SCHEMBL4109875 | 0.77 | BTK (0.44) | LMNA | |
| SCHEMBL8236915 | 0.77 | BTK (0.44) | LMNA | |
| SCHEMBL4104650 | 0.76 | MAPK1 (0.38) | HCAR3DHODHCHEK1OPRK1MAPK1 | |
| SCHEMBL4099139 | 0.75 | DHODH (0.50) | DHODHLMNAGAAALDH1A1TSHR | |
| SCHEMBL12941750 | 0.73 | SYK (0.42) | HCAR3CHEK1OPRK1MAPK1SYK | |
| SCHEMBL21593684 | 0.73 | KMT2A (0.45) | HCAR3CSNK2A1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| WO-2007108750-A1 | PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | PDE4A, PDE4B, PDE12 | HCAR3 2700/4885DHODH 155/4885CHEK1 2961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.