Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 11/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 11/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 11/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 11/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 11/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 11/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 11/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30587634 | 0.75 | HCAR2 (0.41) | HCAR2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL18366320 | 0.75 | HCAR2 (0.41) | HCAR2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4037999 | 0.74 | TYRO3 (0.44) | TYRO3DYRK1BKDM4E | |
| SCHEMBL325244 | 0.72 | HCAR2 (0.36) | HCAR2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL30116778 | 0.72 | LRRK2 (0.36) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL19970146 | 0.72 | TYRO3 (0.42) | TYRO3DYRK1BKDM4EALDH1A1 | |
| SCHEMBL16525458 | 0.72 | TYRO3 (0.42) | TYRO3DYRK1BKDM4E | |
| SCHEMBL30968125 | 0.72 | TYRO3 (0.42) | TYRO3DYRK1BKDM4E | |
| SCHEMBL29454447 | 0.72 | TYRO3 (0.42) | TYRO3DYRK1BKDM4E | |
| SCHEMBL23064021 | 0.70 | HCAR2 (0.40) | HCAR2PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215778-A1 | Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives | PANACOS PHARMACEUTICALS, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| WO-2008134036-A1 | ALPHA-SUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-α]PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215778-A1 | Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives | THPO, DPYD, TPMT | TYRO3 3142/4885DYRK1B 4861/4885HCAR2 3533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.