Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 9/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30343654 | 0.84 | RPS6KB1 (0.38) | GRM4RPS6KB1AKT1DYRK1AWNT1 | |
| SCHEMBL5084942 | 0.84 | RPS6KB1 (0.38) | GRM4RPS6KB1AKT1DYRK1AWNT1 | |
| SCHEMBL352379 | 0.73 | GRM4 (0.39) | GRM4 | |
| SCHEMBL4099666 | 0.72 | TYRO3 (0.41) | HCAR2PRKAG1PRKAA1PRKAB1KMT2A | |
| SCHEMBL5315944 | 0.71 | GRM4 (0.49) | GRM4HAO1TSHRCCNA2CDK2 | |
| SCHEMBL30002581 | 0.71 | HCAR2 (0.36) | HCAR2PRKAG1PRKAA1PRKAB1RPS6KB1 | |
| SCHEMBL16516910 | 0.71 | HCAR2 (0.36) | HCAR2PRKAG1PRKAA1PRKAB1RPS6KB1 | |
| SCHEMBL31133393 | 0.71 | GRM4 (0.49) | GRM4HAO1TSHRCCNA2CDK2 | |
| SCHEMBL1558505 | 0.70 | CSNK2A2 (0.35) | PRKAG1PRKAA1PRKAB1RPS6KB1AKT1 | |
| SCHEMBL473390 | 0.69 | GRM4 (0.46) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118561852-A | Pyrimidopyrazoles oxazolines compound and preparation method and application thereof | 贵州大学 | 2024-08-30 | — | — | CN | disclosed |
| CN-116836168-A | 7-difluoromethyl-5-arylpyrazolopyrimidine compound and preparation and application thereof | 浙江大学 | 2023-10-03 | — | — | CN | disclosed |
| CN-115650984-A | Preparation method of anagliptin | 江苏君若药业有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115650984-A | Preparation method of anagliptin | 江苏君若药业有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-114805469-A | Betulinic acid derivative containing pyrazole, preparation method and application thereof | 中国科学院上海药物研究所 | 2022-07-29 | — | — | CN | disclosed |
| CN-110003219-A | Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator | 弗·哈夫曼-拉罗切有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-105367577-B | Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator | 弗·哈夫曼-拉罗切有限公司 | 2019-04-23 | — | — | CN | disclosed |
| US-20190091195-A1 | USE OF DIANHYDROGALACTITOL AND DERIVATIVES THEREOF IN THE TREATMENT OF GLIOBLASTOMA, LUNG CANCER, AND OVARIAN CANCER | DEL MAR PHARMACEUTICALS (CA) | 2019-03-28 | — | — | US | disclosed |
| CN-106866680-B | A kind of 3- aryl-6-carboxyamide pyrazoles simultaneously [1,5-a] pyrimidines and its application | 陕西理工大学 | 2019-02-01 | — | — | CN | disclosed |
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | HOFFMANN-LA ROCHE INC. | 2018-10-18 | — | — | US | disclosed |
| US-7098335-B2 | Pyrazolopyrimidine compositions | ICAGEN, INC. (US) | 2006-08-29 | — | — | US | disclosed |
| US-20060183756-A1 | Pyrrazolo-pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-17 | — | — | US | disclosed |
| WO-2006084634-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-17 | — | — | WO | disclosed |
| WO-2005123738-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-29 | — | — | WO | disclosed |
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | US | disclosed |
| US-20050215569-A1 | Pyrazolopyrimidines | ICAGEN, INC. (US) | 2005-09-29 | — | — | US | disclosed |
| EP-1506196-A2 | PYRAZOLOPYRIMIDINES | Icagen, Inc. (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6833371-B2 | Contacting cell with a sodium channel-inhibiting amount of a compound comprising a pyrazolopyrimidine moiety for decreasing ion flow through a voltage-dependent sodium channel in a cell | ICAGEN, INC. | 2004-12-21 | — | — | US | disclosed |
| US-20030176450-A1 | Pyrazolopyrimidines | ICAGEN, INC. (US) | 2003-09-18 | — | — | US | disclosed |
| WO-2003037900-A2 | PYRAZOLOPYRIMIDINES | ICAGEN, INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215569-A1 | Pyrazolopyrimidines | SCN3A, TRPV3, P2RX3 | HCAR2 908/4885GRM4 382/4885PRKAG1 1653/4885 |
| US-20050282827-A1 | Pyrazolo-pyrimidine derivatives | P2RX3, P2RX1, P2RX5 | HCAR2 1073/4885GRM4 1300/4885PRKAG1 2063/4885 |
| US-20030176450-A1 | Pyrazolopyrimidines | SCN3A, TRPV3, P2RX3 | HCAR2 908/4885GRM4 382/4885PRKAG1 1653/4885 |
| US-20060183756-A1 | Pyrrazolo-pyrimidine derivatives | GRM1, GRM2, GRM3 | HCAR2 123/4885GRM4 4/4885PRKAG1 1315/4885 |
| US-20190091195-A1 | USE OF DIANHYDROGALACTITOL AND DERIVATIVES THEREOF IN THE TREATMENT OF GLIOBLASTOMA, LUNG CANCER, AND OVARIAN CANCER | DDOST, DCLRE1A, OGG1 | HCAR2 2141/4885GRM4 176/4885PRKAG1 2008/4885 |
| US-20180298026-A1 | Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators | IRAK4, IRAK1, IRAK2 | HCAR2 1536/4885GRM4 135/4885PRKAG1 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.