Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.63 |
| ▸ | JAK3 | P52333 | 3/20 | 0.63 |
| ▸ | JAK1 | P23458 | 2/20 | 0.63 |
| ▸ | TYK2 | P29597 | 2/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.63 |
| ▸ | IKBKB | O14920 | 1/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | HCK | P08631 | 1/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.63 |
| ▸ | PRKCA | P17252 | 1/20 | 0.63 |
| ▸ | PRKACA | P17612 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761824 | 0.85 | JAK2 (0.66) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL5760867 | 0.84 | CHEK1 (0.73) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL5762540 | 0.83 | JAK2 (0.83) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL13740987 | 0.83 | JAK2 (0.48) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL1679510 | 0.82 | JAK2 (0.92) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL8091367 | 0.82 | JAK2 (0.62) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL904545 | 0.82 | JAK2 (0.91) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL29521847 | 0.82 | JAK2 (0.91) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL5761068 | 0.81 | JAK2 (0.64) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL2307059 | 0.81 | JAK2 (0.56) | JAK2JAK3JAK1TYK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | JAK2 2/4885JAK3 3/4885JAK1 1/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | JAK2 2/4885JAK3 3/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.