Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.62 |
| ▸ | JAK3 | P52333 | 3/20 | 0.62 |
| ▸ | JAK1 | P23458 | 2/20 | 0.62 |
| ▸ | TYK2 | P29597 | 2/20 | 0.62 |
| ▸ | IKBKB | O14920 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | HCK | P08631 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.62 |
| ▸ | PRKCA | P17252 | 1/20 | 0.62 |
| ▸ | PRKACA | P17612 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761824 | 0.84 | JAK2 (0.66) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL2302546 | 0.83 | JAK2 (0.59) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL2307561 | 0.83 | JAK2 (0.62) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL4099738 | 0.82 | JAK2 (0.63) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL904545 | 0.81 | JAK2 (0.91) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL29521847 | 0.81 | JAK2 (0.91) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL2303424 | 0.81 | JAK2 (0.59) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL5762466 | 0.80 | JAK2 (0.60) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL2305633 | 0.79 | JAK2 (0.57) | JAK2CHEK1JAK3JAK1TYK2 | |
| SCHEMBL2307963 | 0.79 | CHEK1 (0.58) | JAK2CHEK1JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144011-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | AVALON PHARMACEUTICALS (US) | 2008-11-27 | — | — | WO | disclosed |