Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414224 | 0.92 | AKT1 (0.46) | CDK4CDK2AKT1AKT2IGF1R | |
| SCHEMBL415581 | 0.87 | CDK4 (0.47) | CDK4CDK2IGF1R | |
| SCHEMBL409134 | 0.85 | CDK4 (0.47) | CDK4CDK2IGF1R | |
| SCHEMBL413069 | 0.83 | IGF1R (0.47) | CDK4CDK2IGF1R | |
| SCHEMBL412686 | 0.83 | IGF1R (0.49) | CDK4CDK2AKT1AKT2IGF1R | |
| SCHEMBL408611 | 0.82 | IGF1R (0.47) | CDK4CDK2AKT1AKT2IGF1R | |
| SCHEMBL411785 | 0.82 | IGF1R (0.40) | CDK4CDK2IGF1R | |
| SCHEMBL413247 | 0.81 | IGF1R (0.47) | CDK4CDK2IGF1R | |
| SCHEMBL409975 | 0.81 | IGF1R (0.46) | CDK4CDK2IGF1R | |
| SCHEMBL413288 | 0.81 | AKT1 (0.44) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |